Fresh analysis indicates that patients who stop using new weight-loss injections like Wegovy and Mounjaro may regain lost weight much more quickly than those who stop traditional diet and exercise regimens.
Research printed in a leading medical journal shows that while overweight individuals can lose substantial amounts of their body weight while undergoing treatment, the mass returns at an estimated rate of nearly a kilo each month upon discontinuation.
"People using these treatments need to be informed of the potential of quick rebound weight gain when the therapy ends," stated lead investigator Dr. Susan Jebb.
This pace of recovery means a reversion to pre-treatment mass within about a year and a half.
Weighing Treatments
The analysis, which reviewed dozens of studies involving thousands of participants, contrasted the outcomes of these new drugs with other pills.
Scientists emphasize that people who lose weight through lifestyle changes alone generally see a slower creep back—perhaps 0.1 kg a month—once they finish.
The Reason for the Fast Regain
Experts believe the mechanism of the drugs is key to understanding the amplified regain.
These medications imitate a body's own chemical called glucagon-like peptide-1, which controls hunger.
"Sustained high doses of the hormone levels far above than normal may cause the body to produce less of its own natural GLP-1, and may also reduce sensitivity to its actions," explained Dr. Adam Collins, a dietetics specialist.
"Stopping of this medication leads to appetite is no longer kept in check, making overeating a significant risk."
An Ongoing Disease?
The NHS suggest the injections for individuals with obesity-related medical conditions, alongside prescribed diet and exercise modifications.
A number of clinicians say that, due to the significant potential of relapse, the therapy should be considered life-long.
This opinion is reinforced by drug manufacturers, who state that the findings "highlight the chronic nature of obesity," akin to managing conditions like diabetes.
User Accounts
Individuals who have discontinued the medication describe a intense return of hunger.
"I experienced something flipping and you're instantly extremely hungry," recalled a patient.
This difficulty is worsened if users have not developed permanent lifestyle or habit modifications during therapy.
Significant Use
Survey data show that millions of people in the UK have used weight-loss jabs in the last 12 months, with demand continuing to grow.
- Use is higher among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- Many access the drugs through private healthcare rather than the NHS.
In conclusion, clinicians stress that while these medications are powerful tools for weight loss, they are not a magic cure and maintained weight loss hinges on combined behavioural changes.
